AutomedicationFrancoV1, Main, Exploration, bibRecord, 000377

Uptake of genetic counseling among adult children of BRCA1/2 mutation carriers in France.

Identifieur interne : 000377 ( Main/Exploration ); précédent : 000376; suivant : 000378

Uptake of genetic counseling among adult children of BRCA1/2 mutation carriers in France.

Auteurs : Fatima Belén Gauna Cristaldo [France] ; Rajae Touzani [France] ; Thémis Apostolidis [France] ; Emmanuelle Mouret-Fourme [France] ; Dominique Stoppa-Lyonnet [France] ; Christine Lasset [France] ; Jean-Pierre Fricker [France] ; Pascaline Berthet [France] ; Claire Julian-Reynier [France] ; Julien Mancini [France] ; Catherine Noguès [France] ; Anne-Déborah Bouhnik [France]

Source :

Psycho-oncology [ 1099-1611 ] ; 2019.

RBID : pubmed:31276266

Descripteurs français

KwdFr :
- Acceptation des soins par les patients (psychologie), Adolescent (MeSH), Adulte (MeSH), Adulte d'âge moyen (MeSH), Autorapport (MeSH), Conseil génétique (statistiques et données numériques), Enfants majeurs (psychologie), Enfants majeurs (statistiques et données numériques), Femelle (MeSH), France (MeSH), Gène BRCA1 (MeSH), Gène BRCA2 (MeSH), Humains (MeSH), Hétérozygote (MeSH), Jeune adulte (MeSH), Mutation (MeSH), Mâle (MeSH), Sujet âgé (MeSH), Tumeurs du sein (génétique).
MESH :
- génétique : Tumeurs du sein.
- psychologie : Acceptation des soins par les patients, Enfants majeurs.
- statistiques et données numériques : Conseil génétique, Enfants majeurs.
- Adolescent, Adulte, Adulte d'âge moyen, Autorapport, Femelle, France, Gène BRCA1, Gène BRCA2, Humains, Hétérozygote, Jeune adulte, Mutation, Mâle, Sujet âgé.
Wicri :
- geographic : France.

English descriptors

KwdEn :
- Adolescent (MeSH), Adult (MeSH), Adult Children (psychology), Adult Children (statistics & numerical data), Aged (MeSH), Breast Neoplasms (genetics), Female (MeSH), France (MeSH), Genes, BRCA1 (MeSH), Genes, BRCA2 (MeSH), Genetic Counseling (statistics & numerical data), Heterozygote (MeSH), Humans (MeSH), Male (MeSH), Middle Aged (MeSH), Mutation (MeSH), Patient Acceptance of Health Care (psychology), Self Report (MeSH), Young Adult (MeSH).
MESH :
- geographic : France.
- genetics : Breast Neoplasms.
- psychology : Adult Children, Patient Acceptance of Health Care.
- statistics & numerical data : Adult Children, Genetic Counseling.
- Adolescent, Adult, Aged, Female, Genes, BRCA1, Genes, BRCA2, Heterozygote, Humans, Male, Middle Aged, Mutation, Self Report, Young Adult.

Abstract

OBJECTIVE

Genetic counseling in at-risk families is known to improve cancer prevention. Our study aimed to determine the rate of uptake of genetic counseling among adult children of BRCA1/2 mutation carriers and to identify the potential psychosocial factors associated with uptake of genetic counseling.

METHODS

A self-reported questionnaire was mailed to 328 BRCA1/2 mutation carriers 10 years after BRCA1/2 test disclosure. Of the 233 carriers who returned the questionnaire (response rate = 71%), 135 reported having children over age 18 years and were therefore included in the analysis. Generalized estimating equations models were used to identify the factors associated with uptake of genetic counseling among adult children of mutation carriers.

RESULTS

Data were gathered for a total of 296 children (46% male, 54% female). The vast majority were informed about the familial mutation (90.9%) and 113 (38%; 95% CI, 32%-44%) underwent genetic counseling. This percentage exceeded 80% in women over 40 years. In the multivariate model, female sex, advanced age, mutation in the father, diagnosis of cancer in the mutation-carrying parent after genetic testing, and good family relationships were all factors associated with higher uptake of genetic counseling.

CONCLUSIONS

Adult children of BRCA1/2 mutation carriers in France do not undergo genetic counseling sufficiently often. Further studies should be conducted on the psychosocial factors that hinder the uptake of genetic counseling among adult children of BRCA1/2 mutation carriers.

DOI: 10.1002/pon.5169
PubMed: 31276266

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000434
to stream Main, to step Curation: 000434

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Uptake of genetic counseling among adult children of BRCA1/2 mutation carriers in France.</title>
<author><name sortKey="Gauna Cristaldo, Fatima Belen" sort="Gauna Cristaldo, Fatima Belen" uniqKey="Gauna Cristaldo F" first="Fatima Belén" last="Gauna Cristaldo">Fatima Belén Gauna Cristaldo</name>
<affiliation wicri:level="4"><nlm:affiliation>LPS EA 849, Aix-Marseille Université, Aix-en-Provence, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>LPS EA 849, Aix-Marseille Université, Aix-en-Provence</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Aix-en-Provence</settlement>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Aix-Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Aix-Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Touzani, Rajae" sort="Touzani, Rajae" uniqKey="Touzani R" first="Rajae" last="Touzani">Rajae Touzani</name>
<affiliation wicri:level="3"><nlm:affiliation>Aix-Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Aix-Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>UMR1252, Institut Paoli-Calmettes, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>UMR1252, Institut Paoli-Calmettes, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Apostolidis, Themis" sort="Apostolidis, Themis" uniqKey="Apostolidis T" first="Thémis" last="Apostolidis">Thémis Apostolidis</name>
<affiliation wicri:level="4"><nlm:affiliation>LPS EA 849, Aix-Marseille Université, Aix-en-Provence, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>LPS EA 849, Aix-Marseille Université, Aix-en-Provence</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Aix-en-Provence</settlement>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
<author><name sortKey="Mouret Fourme, Emmanuelle" sort="Mouret Fourme, Emmanuelle" uniqKey="Mouret Fourme E" first="Emmanuelle" last="Mouret-Fourme">Emmanuelle Mouret-Fourme</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Genetics, Institut Curie, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Genetics, Institut Curie, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Genetics, Institut Curie, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Genetics, Institut Curie, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>INSERM U830, Institut Curie, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U830, Institut Curie, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Université Paris Descartes, Sorbonne Paris Cité, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Paris Descartes, Sorbonne Paris Cité, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
<orgName type="university">Université Paris-Descartes</orgName>
</affiliation>
</author>
<author><name sortKey="Lasset, Christine" sort="Lasset, Christine" uniqKey="Lasset C" first="Christine" last="Lasset">Christine Lasset</name>
<affiliation wicri:level="3"><nlm:affiliation>Département de Santé Publique, Centre Léon Bérard, Lyon, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Département de Santé Publique, Centre Léon Bérard, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>CNRS UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Lyon, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CNRS UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Université Claude Bernard Lyon 1, Lyon, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Claude Bernard Lyon 1, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
<orgName type="university">Université Claude Bernard Lyon 1</orgName>
</affiliation>
</author>
<author><name sortKey="Fricker, Jean Pierre" sort="Fricker, Jean Pierre" uniqKey="Fricker J" first="Jean-Pierre" last="Fricker">Jean-Pierre Fricker</name>
<affiliation wicri:level="1"><nlm:affiliation>Service d'Oncogénétique, prévention, dépistage, CLCC Paul Strauss, Strasboug, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service d'Oncogénétique, prévention, dépistage, CLCC Paul Strauss, Strasboug</wicri:regionArea>
<wicri:noRegion>Strasboug</wicri:noRegion>
<wicri:noRegion>Strasboug</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Berthet, Pascaline" sort="Berthet, Pascaline" uniqKey="Berthet P" first="Pascaline" last="Berthet">Pascaline Berthet</name>
<affiliation wicri:level="3"><nlm:affiliation>Service d'oncologie génétique, Centre François Baclesse, Caen, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service d'oncologie génétique, Centre François Baclesse, Caen</wicri:regionArea>
<placeName><region type="region">Région Normandie</region>
<region type="old region">Basse-Normandie</region>
<settlement type="city">Caen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Julian Reynier, Claire" sort="Julian Reynier, Claire" uniqKey="Julian Reynier C" first="Claire" last="Julian-Reynier">Claire Julian-Reynier</name>
<affiliation wicri:level="3"><nlm:affiliation>Aix-Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Aix-Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>UMR1252, Institut Paoli-Calmettes, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>UMR1252, Institut Paoli-Calmettes, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mancini, Julien" sort="Mancini, Julien" uniqKey="Mancini J" first="Julien" last="Mancini">Julien Mancini</name>
<affiliation wicri:level="3"><nlm:affiliation>Aix Marseille Univ, APHM, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, HopTimone, BioSTIC, Biostatistique et Technologies de l'Information et de la Communication, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Aix Marseille Univ, APHM, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, HopTimone, BioSTIC, Biostatistique et Technologies de l'Information et de la Communication, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nogues, Catherine" sort="Nogues, Catherine" uniqKey="Nogues C" first="Catherine" last="Noguès">Catherine Noguès</name>
<affiliation wicri:level="3"><nlm:affiliation>Aix-Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Aix-Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Département d'Anticipation et de Suivi des Cancers, Oncogénétique clinique, Institut Paoli-Calmettes, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Département d'Anticipation et de Suivi des Cancers, Oncogénétique clinique, Institut Paoli-Calmettes, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bouhnik, Anne Deborah" sort="Bouhnik, Anne Deborah" uniqKey="Bouhnik A" first="Anne-Déborah" last="Bouhnik">Anne-Déborah Bouhnik</name>
<affiliation wicri:level="3"><nlm:affiliation>Aix-Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Aix-Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2019">2019</date>
<idno type="RBID">pubmed:31276266</idno>
<idno type="pmid">31276266</idno>
<idno type="doi">10.1002/pon.5169</idno>
<idno type="wicri:Area/Main/Corpus">000434</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000434</idno>
<idno type="wicri:Area/Main/Curation">000434</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000434</idno>
<idno type="wicri:Area/Main/Exploration">000434</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Uptake of genetic counseling among adult children of BRCA1/2 mutation carriers in France.</title>
<author><name sortKey="Gauna Cristaldo, Fatima Belen" sort="Gauna Cristaldo, Fatima Belen" uniqKey="Gauna Cristaldo F" first="Fatima Belén" last="Gauna Cristaldo">Fatima Belén Gauna Cristaldo</name>
<affiliation wicri:level="4"><nlm:affiliation>LPS EA 849, Aix-Marseille Université, Aix-en-Provence, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>LPS EA 849, Aix-Marseille Université, Aix-en-Provence</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Aix-en-Provence</settlement>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Aix-Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Aix-Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Touzani, Rajae" sort="Touzani, Rajae" uniqKey="Touzani R" first="Rajae" last="Touzani">Rajae Touzani</name>
<affiliation wicri:level="3"><nlm:affiliation>Aix-Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Aix-Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>UMR1252, Institut Paoli-Calmettes, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>UMR1252, Institut Paoli-Calmettes, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Apostolidis, Themis" sort="Apostolidis, Themis" uniqKey="Apostolidis T" first="Thémis" last="Apostolidis">Thémis Apostolidis</name>
<affiliation wicri:level="4"><nlm:affiliation>LPS EA 849, Aix-Marseille Université, Aix-en-Provence, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>LPS EA 849, Aix-Marseille Université, Aix-en-Provence</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Aix-en-Provence</settlement>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
<author><name sortKey="Mouret Fourme, Emmanuelle" sort="Mouret Fourme, Emmanuelle" uniqKey="Mouret Fourme E" first="Emmanuelle" last="Mouret-Fourme">Emmanuelle Mouret-Fourme</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Genetics, Institut Curie, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Genetics, Institut Curie, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Genetics, Institut Curie, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Genetics, Institut Curie, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>INSERM U830, Institut Curie, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U830, Institut Curie, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Université Paris Descartes, Sorbonne Paris Cité, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Paris Descartes, Sorbonne Paris Cité, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
<orgName type="university">Université Paris-Descartes</orgName>
</affiliation>
</author>
<author><name sortKey="Lasset, Christine" sort="Lasset, Christine" uniqKey="Lasset C" first="Christine" last="Lasset">Christine Lasset</name>
<affiliation wicri:level="3"><nlm:affiliation>Département de Santé Publique, Centre Léon Bérard, Lyon, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Département de Santé Publique, Centre Léon Bérard, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>CNRS UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Lyon, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CNRS UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Université Claude Bernard Lyon 1, Lyon, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Claude Bernard Lyon 1, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
<orgName type="university">Université Claude Bernard Lyon 1</orgName>
</affiliation>
</author>
<author><name sortKey="Fricker, Jean Pierre" sort="Fricker, Jean Pierre" uniqKey="Fricker J" first="Jean-Pierre" last="Fricker">Jean-Pierre Fricker</name>
<affiliation wicri:level="1"><nlm:affiliation>Service d'Oncogénétique, prévention, dépistage, CLCC Paul Strauss, Strasboug, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service d'Oncogénétique, prévention, dépistage, CLCC Paul Strauss, Strasboug</wicri:regionArea>
<wicri:noRegion>Strasboug</wicri:noRegion>
<wicri:noRegion>Strasboug</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Berthet, Pascaline" sort="Berthet, Pascaline" uniqKey="Berthet P" first="Pascaline" last="Berthet">Pascaline Berthet</name>
<affiliation wicri:level="3"><nlm:affiliation>Service d'oncologie génétique, Centre François Baclesse, Caen, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service d'oncologie génétique, Centre François Baclesse, Caen</wicri:regionArea>
<placeName><region type="region">Région Normandie</region>
<region type="old region">Basse-Normandie</region>
<settlement type="city">Caen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Julian Reynier, Claire" sort="Julian Reynier, Claire" uniqKey="Julian Reynier C" first="Claire" last="Julian-Reynier">Claire Julian-Reynier</name>
<affiliation wicri:level="3"><nlm:affiliation>Aix-Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Aix-Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>UMR1252, Institut Paoli-Calmettes, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>UMR1252, Institut Paoli-Calmettes, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mancini, Julien" sort="Mancini, Julien" uniqKey="Mancini J" first="Julien" last="Mancini">Julien Mancini</name>
<affiliation wicri:level="3"><nlm:affiliation>Aix Marseille Univ, APHM, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, HopTimone, BioSTIC, Biostatistique et Technologies de l'Information et de la Communication, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Aix Marseille Univ, APHM, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, HopTimone, BioSTIC, Biostatistique et Technologies de l'Information et de la Communication, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nogues, Catherine" sort="Nogues, Catherine" uniqKey="Nogues C" first="Catherine" last="Noguès">Catherine Noguès</name>
<affiliation wicri:level="3"><nlm:affiliation>Aix-Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Aix-Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Département d'Anticipation et de Suivi des Cancers, Oncogénétique clinique, Institut Paoli-Calmettes, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Département d'Anticipation et de Suivi des Cancers, Oncogénétique clinique, Institut Paoli-Calmettes, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bouhnik, Anne Deborah" sort="Bouhnik, Anne Deborah" uniqKey="Bouhnik A" first="Anne-Déborah" last="Bouhnik">Anne-Déborah Bouhnik</name>
<affiliation wicri:level="3"><nlm:affiliation>Aix-Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Aix-Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Psycho-oncology</title>
<idno type="eISSN">1099-1611</idno>
<imprint><date when="2019" type="published">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term>
<term>Adult (MeSH)</term>
<term>Adult Children (psychology)</term>
<term>Adult Children (statistics & numerical data)</term>
<term>Aged (MeSH)</term>
<term>Breast Neoplasms (genetics)</term>
<term>Female (MeSH)</term>
<term>France (MeSH)</term>
<term>Genes, BRCA1 (MeSH)</term>
<term>Genes, BRCA2 (MeSH)</term>
<term>Genetic Counseling (statistics & numerical data)</term>
<term>Heterozygote (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Mutation (MeSH)</term>
<term>Patient Acceptance of Health Care (psychology)</term>
<term>Self Report (MeSH)</term>
<term>Young Adult (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Acceptation des soins par les patients (psychologie)</term>
<term>Adolescent (MeSH)</term>
<term>Adulte (MeSH)</term>
<term>Adulte d'âge moyen (MeSH)</term>
<term>Autorapport (MeSH)</term>
<term>Conseil génétique (statistiques et données numériques)</term>
<term>Enfants majeurs (psychologie)</term>
<term>Enfants majeurs (statistiques et données numériques)</term>
<term>Femelle (MeSH)</term>
<term>France (MeSH)</term>
<term>Gène BRCA1 (MeSH)</term>
<term>Gène BRCA2 (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Hétérozygote (MeSH)</term>
<term>Jeune adulte (MeSH)</term>
<term>Mutation (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Sujet âgé (MeSH)</term>
<term>Tumeurs du sein (génétique)</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>France</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Breast Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Tumeurs du sein</term>
</keywords>
<keywords scheme="MESH" qualifier="psychologie" xml:lang="fr"><term>Acceptation des soins par les patients</term>
<term>Enfants majeurs</term>
</keywords>
<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Adult Children</term>
<term>Patient Acceptance of Health Care</term>
</keywords>
<keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Adult Children</term>
<term>Genetic Counseling</term>
</keywords>
<keywords scheme="MESH" qualifier="statistiques et données numériques" xml:lang="fr"><term>Conseil génétique</term>
<term>Enfants majeurs</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Female</term>
<term>Genes, BRCA1</term>
<term>Genes, BRCA2</term>
<term>Heterozygote</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Mutation</term>
<term>Self Report</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Autorapport</term>
<term>Femelle</term>
<term>France</term>
<term>Gène BRCA1</term>
<term>Gène BRCA2</term>
<term>Humains</term>
<term>Hétérozygote</term>
<term>Jeune adulte</term>
<term>Mutation</term>
<term>Mâle</term>
<term>Sujet âgé</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>France</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b>
</p>
<p>Genetic counseling in at-risk families is known to improve cancer prevention. Our study aimed to determine the rate of uptake of genetic counseling among adult children of BRCA1/2 mutation carriers and to identify the potential psychosocial factors associated with uptake of genetic counseling.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>A self-reported questionnaire was mailed to 328 BRCA1/2 mutation carriers 10 years after BRCA1/2 test disclosure. Of the 233 carriers who returned the questionnaire (response rate = 71%), 135 reported having children over age 18 years and were therefore included in the analysis. Generalized estimating equations models were used to identify the factors associated with uptake of genetic counseling among adult children of mutation carriers.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Data were gathered for a total of 296 children (46% male, 54% female). The vast majority were informed about the familial mutation (90.9%) and 113 (38%; 95% CI, 32%-44%) underwent genetic counseling. This percentage exceeded 80% in women over 40 years. In the multivariate model, female sex, advanced age, mutation in the father, diagnosis of cancer in the mutation-carrying parent after genetic testing, and good family relationships were all factors associated with higher uptake of genetic counseling.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>Adult children of BRCA1/2 mutation carriers in France do not undergo genetic counseling sufficiently often. Further studies should be conducted on the psychosocial factors that hinder the uptake of genetic counseling among adult children of BRCA1/2 mutation carriers.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">31276266</PMID>
<DateCompleted><Year>2020</Year>
<Month>03</Month>
<Day>16</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>03</Month>
<Day>16</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1099-1611</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>28</Volume>
<Issue>9</Issue>
<PubDate><Year>2019</Year>
<Month>09</Month>
</PubDate>
</JournalIssue>
<Title>Psycho-oncology</Title>
<ISOAbbreviation>Psychooncology</ISOAbbreviation>
</Journal>
<ArticleTitle>Uptake of genetic counseling among adult children of BRCA1/2 mutation carriers in France.</ArticleTitle>
<Pagination><MedlinePgn>1894-1900</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1002/pon.5169</ELocationID>
<Abstract><AbstractText Label="OBJECTIVE">Genetic counseling in at-risk families is known to improve cancer prevention. Our study aimed to determine the rate of uptake of genetic counseling among adult children of BRCA1/2 mutation carriers and to identify the potential psychosocial factors associated with uptake of genetic counseling.</AbstractText>
<AbstractText Label="METHODS">A self-reported questionnaire was mailed to 328 BRCA1/2 mutation carriers 10 years after BRCA1/2 test disclosure. Of the 233 carriers who returned the questionnaire (response rate = 71%), 135 reported having children over age 18 years and were therefore included in the analysis. Generalized estimating equations models were used to identify the factors associated with uptake of genetic counseling among adult children of mutation carriers.</AbstractText>
<AbstractText Label="RESULTS">Data were gathered for a total of 296 children (46% male, 54% female). The vast majority were informed about the familial mutation (90.9%) and 113 (38%; 95% CI, 32%-44%) underwent genetic counseling. This percentage exceeded 80% in women over 40 years. In the multivariate model, female sex, advanced age, mutation in the father, diagnosis of cancer in the mutation-carrying parent after genetic testing, and good family relationships were all factors associated with higher uptake of genetic counseling.</AbstractText>
<AbstractText Label="CONCLUSIONS">Adult children of BRCA1/2 mutation carriers in France do not undergo genetic counseling sufficiently often. Further studies should be conducted on the psychosocial factors that hinder the uptake of genetic counseling among adult children of BRCA1/2 mutation carriers.</AbstractText>
<CopyrightInformation>© 2019 John Wiley & Sons, Ltd.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gauna Cristaldo</LastName>
<ForeName>Fatima Belén</ForeName>
<Initials>FB</Initials>
<AffiliationInfo><Affiliation>LPS EA 849, Aix-Marseille Université, Aix-en-Provence, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Aix-Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, Marseille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Touzani</LastName>
<ForeName>Rajae</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Aix-Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, Marseille, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>UMR1252, Institut Paoli-Calmettes, Marseille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Apostolidis</LastName>
<ForeName>Thémis</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>LPS EA 849, Aix-Marseille Université, Aix-en-Provence, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mouret-Fourme</LastName>
<ForeName>Emmanuelle</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Department of Genetics, Institut Curie, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Stoppa-Lyonnet</LastName>
<ForeName>Dominique</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Department of Genetics, Institut Curie, Paris, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>INSERM U830, Institut Curie, Paris, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Université Paris Descartes, Sorbonne Paris Cité, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lasset</LastName>
<ForeName>Christine</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Département de Santé Publique, Centre Léon Bérard, Lyon, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>CNRS UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Lyon, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Université Claude Bernard Lyon 1, Lyon, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fricker</LastName>
<ForeName>Jean-Pierre</ForeName>
<Initials>JP</Initials>
<AffiliationInfo><Affiliation>Service d'Oncogénétique, prévention, dépistage, CLCC Paul Strauss, Strasboug, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Berthet</LastName>
<ForeName>Pascaline</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Service d'oncologie génétique, Centre François Baclesse, Caen, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Julian-Reynier</LastName>
<ForeName>Claire</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Aix-Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, Marseille, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>UMR1252, Institut Paoli-Calmettes, Marseille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mancini</LastName>
<ForeName>Julien</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Aix Marseille Univ, APHM, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, HopTimone, BioSTIC, Biostatistique et Technologies de l'Information et de la Communication, Marseille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Noguès</LastName>
<ForeName>Catherine</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Aix-Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, Marseille, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Département d'Anticipation et de Suivi des Cancers, Oncogénétique clinique, Institut Paoli-Calmettes, Marseille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bouhnik</LastName>
<ForeName>Anne-Déborah</ForeName>
<Initials>AD</Initials>
<Identifier Source="ORCID">0000-0002-5418-4592</Identifier>
<AffiliationInfo><Affiliation>Aix-Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, Marseille, France.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2019</Year>
<Month>07</Month>
<Day>17</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Psychooncology</MedlineTA>
<NlmUniqueID>9214524</NlmUniqueID>
<ISSNLinking>1057-9249</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D032721" MajorTopicYN="N">Adult Children</DescriptorName>
<QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName>
<QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001943" MajorTopicYN="N">Breast Neoplasms</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005602" MajorTopicYN="N" Type="Geographic">France</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019398" MajorTopicYN="Y">Genes, BRCA1</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D024522" MajorTopicYN="Y">Genes, BRCA2</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005817" MajorTopicYN="N">Genetic Counseling</DescriptorName>
<QualifierName UI="Q000706" MajorTopicYN="Y">statistics & numerical data</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006579" MajorTopicYN="N">Heterozygote</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009154" MajorTopicYN="N">Mutation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010342" MajorTopicYN="N">Patient Acceptance of Health Care</DescriptorName>
<QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D057566" MajorTopicYN="N">Self Report</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">BRCA1/2</Keyword>
<Keyword MajorTopicYN="Y">cancer</Keyword>
<Keyword MajorTopicYN="Y">children</Keyword>
<Keyword MajorTopicYN="Y">family relationships</Keyword>
<Keyword MajorTopicYN="Y">gender</Keyword>
<Keyword MajorTopicYN="Y">genetic counseling</Keyword>
<Keyword MajorTopicYN="Y">oncology</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year>
<Month>03</Month>
<Day>22</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2019</Year>
<Month>06</Month>
<Day>05</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2019</Year>
<Month>07</Month>
<Day>01</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2019</Year>
<Month>7</Month>
<Day>6</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>3</Month>
<Day>17</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2019</Year>
<Month>7</Month>
<Day>6</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">31276266</ArticleId>
<ArticleId IdType="doi">10.1002/pon.5169</ArticleId>
</ArticleIdList>
<ReferenceList><Title>REFERENCES</Title>
<Reference><Citation>Lodder L, Frets PG, Trijsburg RW, et al. Men at risk of being a mutation carrier for hereditary breast/ovarian cancer: an exploration of attitudes and psychological functioning during genetic testing. Eur J Hum Genet. 2001;9(7):492-500.</Citation>
</Reference>
<Reference><Citation>Black L, McClellan KA, Avard D, Knoppers BM. Intrafamilial disclosure of risk for hereditary breast and ovarian cancer: points to consider. J Community Genet. 2013;4(2):203-214.</Citation>
</Reference>
<Reference><Citation>Bradbury AR, Dignam JJ, Ibe CN, et al. How often do BRCA mutation carriers tell their young children of the family's risk for cancer? A study of parental disclosure of BRCA mutations to minors and young adults. J Clin Oncol. 2007;25(24):3705-3711.</Citation>
</Reference>
<Reference><Citation>Christophe V, Leroy T, Adenis C, Reich M, Vennin P. Information spreading about hereditary carriage of a BRCA1/2 mutation and ovarian cancer and rate of consultation of the concerned relatives. Bull Cancer. 2008;95(4):395-402.</Citation>
</Reference>
<Reference><Citation>Patenaude AF, Tung N, Ryan PD, et al. Young adult daughters of BRCA1/2 positive mothers: what do they know about hereditary cancer and how much do they worry? Psychooncology. 2013;22(9):2024-2031.</Citation>
</Reference>
<Reference><Citation>Troïan J, Apostolidis T, Touzani R, et al. Genetic information disclosure to offspring in BRCA mutation carriers. Kuala-Lumpur, Malaysia: IMPAHC: International Meeting on Psycho-social Aspects of Hereditary Cancer; 2017.</Citation>
</Reference>
<Reference><Citation>Wiseman M, Dancyger C, Michie S. Communicating genetic risk information within families: a review. Fam Cancer. 2010;9(4):691-703.</Citation>
</Reference>
<Reference><Citation>Lu KH, Wood ME, Daniels M, et al. American Society of Clinical Oncology Expert Statement: collection and use of a cancer family history for oncology providers. J Clin Oncol. 2014;32(8):833-840.</Citation>
</Reference>
<Reference><Citation>Kuchenbaecker KB, Hopper JL, Barnes DR, et al. Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers. JAMA. 2017;317(23):2402-2416.</Citation>
</Reference>
<Reference><Citation>Nelson HD, Pappas M, Zakher B, Mitchell JP, Okinaka-Hu L, Fu R. Risk assessment, genetic counseling, and genetic testing for BRCA-related cancer in women: a systematic review to update the U.S. Preventive Services Task Force recommendation. Ann Intern Med. 2014;160(4):255-266.</Citation>
</Reference>
<Reference><Citation>den Heijer M, Seynaeve C, Vanheusden K, et al. Psychological distress in women at risk for hereditary breast cancer: the role of family communication and perceived social support. Psychooncology. 2011;20(12):1317-1323.</Citation>
</Reference>
<Reference><Citation>Julian-Reynier C, Mancini J, Mouret-Fourme E, et al. Cancer risk management strategies and perceptions of unaffected women 5 years after predictive genetic testing for BRCA1/2 mutations. Eur J Hum Genet. 2011;19(5):500-506.</Citation>
</Reference>
<Reference><Citation>Dorval M, Nogues C, Berthet P, et al. Breast and ovarian cancer screening of non-carriers from BRCA1/2 mutation-positive families: 2-year follow-up of cohorts from France and Quebec. Eur J Hum Genet. 2011;19(5):494-499.</Citation>
</Reference>
<Reference><Citation>Julian-Reynier C, Bouhnik AD, Mouret-Fourme E, et al. Time to prophylactic surgery in BRCA1/2 carriers depends on psychological and other characteristics. Genet Med. 2010;12(12):801-807.</Citation>
</Reference>
<Reference><Citation>Maheu C, Apostolidis T, Petri-Cal A, et al. French women's breast self-examination practices with time after undergoing BRCA1/2 genetic testing. Fam Cancer. 2012;11(2):269-278.</Citation>
</Reference>
<Reference><Citation>Hesse-Biber S, An C. Within-gender differences in medical decision making among male carriers of the BRCA genetic mutation for hereditary breast cancer. Am J Mens Health. 2017;11(5):1444-1459.</Citation>
</Reference>
<Reference><Citation>Daly MB. The impact of social roles on the experience of men in BRCA1/2 families: implications for counseling. J Genet Couns. 2009;18(1):42-48.</Citation>
</Reference>
<Reference><Citation>Kissane DW, Bloch S. Family focused grief therapy: a model of family-centered care during palliative care and bereavement. Buckingham: Open University Press; 2002.</Citation>
</Reference>
<Reference><Citation>Young AL, Butow PN, Vetsch J, et al. Family communication, risk perception and cancer knowledge of young adults from BRCA1/2 families: a systematic review. J Genet Couns. 2017;26(6):1179-1196.</Citation>
</Reference>
<Reference><Citation>Pujol P, Lyonnet DS, Frebourg T, et al. Lack of referral for genetic counseling and testing in BRCA1/2 and Lynch syndromes: a nationwide study based on 240,134 consultations and 134,652 genetic tests. Breast Cancer Res Treat. 2013;141(1):135-144.</Citation>
</Reference>
<Reference><Citation>Julian-Reynier C, Resseguier N, Bouhnik AD, et al. Cigarette smoking in women after BRCA1/2 genetic test disclosure: a 5-year follow-up study of the GENEPSO PS cohort. Genet Med. 2015;17(2):117-124.</Citation>
</Reference>
<Reference><Citation>Moos RH, Moos BS. Family environment scale manual. Pao Alto, CA: Consulting Psychologists Press; 1981.</Citation>
</Reference>
<Reference><Citation>Untas A, Rascle N, Cosnefroy O, Borteyrou X, Saada Y, Koleck M. Psychometric properties of the French adaptation of the Family Relationship Index (FRI). Encéphale. 2011;37(2):110-118.</Citation>
</Reference>
<Reference><Citation>Ziegler A, Kastner C, Blettner M. The generalized estimating equations: an annotated bibliography. Biom J: J Math Methods Biosci. 1998;40(2):115-139.</Citation>
</Reference>
<Reference><Citation>Daly PA, Nolan C, Green A, et al. Predictive testing for BRCA1 and 2 mutations: a male contribution. Ann Oncol. 2003;14(4):549-553.</Citation>
</Reference>
<Reference><Citation>Evans DG, Binchy A, Shenton A, Hopwood P, Craufurd D. Comparison of proactive and usual approaches to offering predictive testing for BRCA1/2 mutations in unaffected relatives. Clin Genet. 2009;75(2):124-132.</Citation>
</Reference>
<Reference><Citation>Narod SA, Neuhausen S, Vichodez G, et al. Rapid progression of prostate cancer in men with a BRCA2 mutation. Br J Cancer. 2008;99(2):371-374.</Citation>
</Reference>
<Reference><Citation>Engel C, Fischer C. Breast cancer risks and risk prediction models. Breast Care (Basel). 2015;10(1):7-12.</Citation>
</Reference>
<Reference><Citation>Miron-Shatz T, Hanoch Y, Katz BA, Doniger GM, Ozanne EM. Willingness to test for BRCA1/2 in high risk women: influenced by risk perception and family experience, rather than by objective or subjective numeracy? Judgm Decis Mak. 2015;10(4):386-399.</Citation>
</Reference>
<Reference><Citation>Marteau TM, Weinman J. Self-regulation and the behavioural response to DNA risk information: a theoretical analysis and framework for future research. Soc Sci Med. 2006;62(6):1360-1368.</Citation>
</Reference>
<Reference><Citation>Nycum G, Avard D, Knoppers BM. Factors influencing intrafamilial communication of hereditary breast and ovarian cancer genetic information. Eur J Hum Genet. 2009;17(7):872-880.</Citation>
</Reference>
<Reference><Citation>Hallowell N, Ardern-Jones A, Eeles R, et al. Communication about genetic testing in families of male BRCA1/2 carriers and non-carriers: patterns, priorities and problems. Clin Genet. 2005;67(6):492-502.</Citation>
</Reference>
<Reference><Citation>Héritier F. Masculin/Féminin. La pensée de la différence. Paris: Odile Jacob; 1996.</Citation>
</Reference>
<Reference><Citation>Aim MA, Lelaurain S, Khatmi N, Fonte D, Bovina I, Dany L. 'Similar but different': social representations of health according to gender for French youth. J Health Psychol. June 19, 2018, 135910531878189. https://doi.org/10.1177/1359105318781894 [Epub ahead of print]</Citation>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>France</li>
</country>
<region><li>Auvergne-Rhône-Alpes</li>
<li>Basse-Normandie</li>
<li>Provence-Alpes-Côte d'Azur</li>
<li>Rhône-Alpes</li>
<li>Région Normandie</li>
<li>Île-de-France</li>
</region>
<settlement><li>Aix-en-Provence</li>
<li>Caen</li>
<li>Lyon</li>
<li>Marseille</li>
<li>Paris</li>
</settlement>
<orgName><li>Université Claude Bernard Lyon 1</li>
<li>Université Paris-Descartes</li>
<li>Université d'Aix-Marseille</li>
</orgName>
</list>
<tree><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Gauna Cristaldo, Fatima Belen" sort="Gauna Cristaldo, Fatima Belen" uniqKey="Gauna Cristaldo F" first="Fatima Belén" last="Gauna Cristaldo">Fatima Belén Gauna Cristaldo</name>
</region>
<name sortKey="Apostolidis, Themis" sort="Apostolidis, Themis" uniqKey="Apostolidis T" first="Thémis" last="Apostolidis">Thémis Apostolidis</name>
<name sortKey="Berthet, Pascaline" sort="Berthet, Pascaline" uniqKey="Berthet P" first="Pascaline" last="Berthet">Pascaline Berthet</name>
<name sortKey="Bouhnik, Anne Deborah" sort="Bouhnik, Anne Deborah" uniqKey="Bouhnik A" first="Anne-Déborah" last="Bouhnik">Anne-Déborah Bouhnik</name>
<name sortKey="Fricker, Jean Pierre" sort="Fricker, Jean Pierre" uniqKey="Fricker J" first="Jean-Pierre" last="Fricker">Jean-Pierre Fricker</name>
<name sortKey="Gauna Cristaldo, Fatima Belen" sort="Gauna Cristaldo, Fatima Belen" uniqKey="Gauna Cristaldo F" first="Fatima Belén" last="Gauna Cristaldo">Fatima Belén Gauna Cristaldo</name>
<name sortKey="Julian Reynier, Claire" sort="Julian Reynier, Claire" uniqKey="Julian Reynier C" first="Claire" last="Julian-Reynier">Claire Julian-Reynier</name>
<name sortKey="Julian Reynier, Claire" sort="Julian Reynier, Claire" uniqKey="Julian Reynier C" first="Claire" last="Julian-Reynier">Claire Julian-Reynier</name>
<name sortKey="Lasset, Christine" sort="Lasset, Christine" uniqKey="Lasset C" first="Christine" last="Lasset">Christine Lasset</name>
<name sortKey="Lasset, Christine" sort="Lasset, Christine" uniqKey="Lasset C" first="Christine" last="Lasset">Christine Lasset</name>
<name sortKey="Lasset, Christine" sort="Lasset, Christine" uniqKey="Lasset C" first="Christine" last="Lasset">Christine Lasset</name>
<name sortKey="Mancini, Julien" sort="Mancini, Julien" uniqKey="Mancini J" first="Julien" last="Mancini">Julien Mancini</name>
<name sortKey="Mouret Fourme, Emmanuelle" sort="Mouret Fourme, Emmanuelle" uniqKey="Mouret Fourme E" first="Emmanuelle" last="Mouret-Fourme">Emmanuelle Mouret-Fourme</name>
<name sortKey="Nogues, Catherine" sort="Nogues, Catherine" uniqKey="Nogues C" first="Catherine" last="Noguès">Catherine Noguès</name>
<name sortKey="Nogues, Catherine" sort="Nogues, Catherine" uniqKey="Nogues C" first="Catherine" last="Noguès">Catherine Noguès</name>
<name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name>
<name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name>
<name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name>
<name sortKey="Touzani, Rajae" sort="Touzani, Rajae" uniqKey="Touzani R" first="Rajae" last="Touzani">Rajae Touzani</name>
<name sortKey="Touzani, Rajae" sort="Touzani, Rajae" uniqKey="Touzani R" first="Rajae" last="Touzani">Rajae Touzani</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/AutomedicationFrancoV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000377 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000377 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    AutomedicationFrancoV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:31276266
   |texte=   Uptake of genetic counseling among adult children of BRCA1/2 mutation carriers in France.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:31276266" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a AutomedicationFrancoV1

This area was generated with Dilib version V0.6.38.
Data generation: Mon Mar 15 15:24:36 2021. Site generation: Mon Mar 15 15:32:03 2021

	Serveur d'exploration sur l'automédication dans le monde francophone
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur l'automédication dans le monde francophone

Uptake of genetic counseling among adult children of BRCA1/2 mutation carriers in France.

Uptake of genetic counseling among adult children of BRCA1/2 mutation carriers in France.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki